v. 2, n. 3, (2021)

Major Approaches to the Dosage of Vitamin D in the Elderly: A Systematic Review

Moniele Matos Cadamuro
MANZINI CLINIC - General Medical Practice, Nutrology, and Health Sciences, Votuporanga, Sao Paulo, Brazil.
Durval Ribas Filho
ABRAN - Associação Brasileira de Nutrologia /Brazilian Association of Nutrology, Catanduva/SP, Brazil.

Published 2021-06-09


  • Elderly,
  • Vitamin D,
  • 25 (OH) D,
  • Hypovitaminosis,
  • Immunity,
  • Inflammatory Process
  • ...More

How to Cite

Cadamuro, M. M., & Filho, D. R. (2021). Major Approaches to the Dosage of Vitamin D in the Elderly: A Systematic Review. MedNEXT Journal of Medical and Health Sciences, 2(3), 1–5. https://doi.org/10.34256/mdnt2131


Introduction: In the scenario of vitamin D deficiency, this incident is prevalent and with risks to public health in the world, reaching approximately 90% of individuals. Hypovitaminosis D can cause, mainly in the elderly, lower bone mineral density, fractures, muscle weakness, falls, and acute respiratory infection. Objective: To evaluate the main clinical results on vitamin D levels in the elderly, as well as to analyze which daily or weekly dose of vitamin D is most effective in the elderly in reducing the number of falls and fractures. Methods: The present study developed a systematic review, addressing randomized clinical studies, diverse clinical studies, systematic reviews, meta-analysis, and the latest international consensus, following the rules of PRISMA. Results and Conclusion: A total of 152 articles were found involving the dosage and the impact of vitamin D in the elderly. In total, 72 articles were evaluated in full and 30 were included. According to the main literary findings, vitamin D deficiency implies problems with mineralization and bone mineral density, causing fractures and an increase in the number of elderly falls. In this sense, SBEM recommends maintaining vitamin D concentrations above 30 ng/mL. Also, vitamin D deficiency points to the occurrence of neurological diseases such as cognitive decline, risk of Alzheimer's disease, and depression. In the current scenario of the pandemic, vitamin D points as an important modulator of the immune system, and its deficiency promotes the unregulated release of cytokines, leading to complications in patients with COVID-19.


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